Non-immunosuppressive FTY720-derivative OSU-2S mediates reactive oxygen species mediated cytotoxicity in canine B-cell lymphoma

OSU-2S is a FTY720 (Fingolimod) derivative that lacks immunosuppressive properties but exhibits strong anti-tumor activity in several hematological and solid tumor models. We have recently shown OSU-2S to mediate potent cytotoxicity in human mantle cell lymphoma cell lines and primary cells. We repo...

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Pubblicato in:Vet Comp Oncol
Autori principali: Mani, Rajeswaran, Yan, Ribai, Mo, Xiaokui, Chen, Ching-Shih, Phelps, Mitch A., Klisovic, Rebecca, Byrd, John C., Kisseberth, William C., London, Cheryl A., Muthusamy, Natarajan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093090/
https://ncbi.nlm.nih.gov/pubmed/27136276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/vco.12221
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