Quantification of OSU-2S, a novel derivative of FTY720, in mouse plasma by liquid chromatography-tandem mass spectrometry

OSU-2S is a novel anti-cancer and immune modulatory agent designed specifically to avert the immunosuppressive effects and related toxicities observed in clinical studies with its predecessor analog, FTY720. To characterize its preclinical pharmacokinetics, a liquid chromatography-tandem mass spectr...

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Bibliographische Detailangaben
Hauptverfasser: Mao, Yicheng, Wang, Jiang, Zhao, Yuan, Yan, Ribai, Li, Hao, Chen, Ching-Shih, Lee, Robert J., Byrd, John C., Lee, L. James, Muthusamy, Natarajan, Phelps, Mitch A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180035/
https://ncbi.nlm.nih.gov/pubmed/24927402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2014.05.022
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