Blockade of NF-κB and MAPK pathways by ulinastatin attenuates wear particle-stimulated osteoclast differentiation in vitro and in vivo

Ulinastatin, a urinary trypsin inhibitor (UTI), is widely used to clinically treat lipopolysaccharide (LPS)-related inflammatory disorders recently. Adherent pathogen-associated molecular patterns (PAMPs), of which LPS is the best-studied and classical endotoxin produced by Gram-negative bacteria, a...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Ru, Jiang-Ying, Xu, Hai-Dong, Shi, Dai, Pan, Jun-Bo, Pan, Xiao-Jin, Wang, Yan-Fen
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2016
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Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5091469/
https://ncbi.nlm.nih.gov/pubmed/27638499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20160234
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