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Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption by suppressing MAPK, NF-κB and AKT signalling pathways and promotes Caspase3-mediated apoptosis of mature osteoclasts

Osteoclasts are multinuclear giant cells that have unique ability to degrade bone. The search for new medicines that modulate the formation and function of osteoclasts is a potential approach for treating osteoclast-related bone diseases. Piceatannol (PIC) is a natural organic polyphenolic stilbene...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:R Soc Open Sci
Main Authors: Yan, Liuliu, Lu, Lulu, Hu, Fangbin, Shetti, Dattatrya, Wei, Kun
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599799/
https://ncbi.nlm.nih.gov/pubmed/31312498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.190360
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