Niloticin inhibits osteoclastogenesis by blocking RANKL–RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways

Dysregulation of osteoclasts or excessive osteoclastogenesis significantly –contributes to the occurrence and development of osteolytic diseases, including osteoporosis, inflammatory bone erosion, and tumor-induced osteolysis. The protein-protein interaction between the receptor activator of nuclear...

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Detalhes bibliográficos
Main Authors: Huanhuan Xu, Yuankan Jia, Jin Li, Xueqin Huang, Li Jiang, Ting Xiang, Yuanhao Xie, Xiaomei Yang, Titi Liu, Zemin Xiang, Jun Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-05-01
Colecção:Biomedicine & Pharmacotherapy
Assuntos:
Osteoclastogenesis
Niloticin
RANKL–RANK interaction
NF-κB
MAPK
AKT
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0753332222002918
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