Tereticornate A suppresses RANKL-induced osteoclastogenesis via the downregulation of c-Src and TRAF6 and the inhibition of RANK signaling pathways

Excessive osteoclast differentiation and activation are closely associated with the development and progression of osteoporosis. Natural plant-derived compounds that can inhibit osteoclastogenesis are an efficient strategy for the prevention and treatment of osteoporosis. Tereticornate A (TA) is a n...

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Detalhes bibliográficos
Main Authors: Titi Liu, Li Jiang, Zemin Xiang, Jin Li, Yaqi Zhang, Ting Xiang, Wei Wang, Xiaofeng Li, Yuankan Jia, Xueqin Huang, Xiaofang Lu, Huanhuan Xu, Xuanjun Wang, Jun Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-07-01
Colecção:Biomedicine & Pharmacotherapy
Assuntos:
Tereticornate A
Osteoclastogenesis
C-Src
TRAF6
RANK signaling
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0753332222005297
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