RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors

Cytokines, including receptor activator of nuclear factor κB ligand (RANKL) and TNF, induce increased osteoclast (OC) formation and bone loss in postmenopausal osteoporosis and inflammatory arthritides. RANKL and TNF can independently induce OC formation in vitro from WT OC precursors via TNF recept...

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Publicado en:J Biol Chem
Autores principales: Yao, Zhenqiang, Lei, Wei, Duan, Rong, Li, Yanyun, Luo, Lu, Boyce, Brendan F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473222/
https://ncbi.nlm.nih.gov/pubmed/28438834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.771816
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