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RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors

Cytokines, including receptor activator of nuclear factor κB ligand (RANKL) and TNF, induce increased osteoclast (OC) formation and bone loss in postmenopausal osteoporosis and inflammatory arthritides. RANKL and TNF can independently induce OC formation in vitro from WT OC precursors via TNF recept...

詳細記述

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書誌詳細
出版年:J Biol Chem
主要な著者: Yao, Zhenqiang, Lei, Wei, Duan, Rong, Li, Yanyun, Luo, Lu, Boyce, Brendan F.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473222/
https://ncbi.nlm.nih.gov/pubmed/28438834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.771816
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