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Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation
The cytokines RANKL and TNF activate NF-κB signaling in osteoclast precursors (OCPs) to induce osteoclast (OC) formation. Conversely, TNF can limit OC formation through NF-κB p100, which acts as an inhibitor, and TNF receptor–associated receptor 3 (TRAF3); however, a role for TRAF3 in RANKL-mediated...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Clinical Investigation
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3871219/ https://ncbi.nlm.nih.gov/pubmed/24316970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66947 |
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