Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation

The cytokines RANKL and TNF activate NF-κB signaling in osteoclast precursors (OCPs) to induce osteoclast (OC) formation. Conversely, TNF can limit OC formation through NF-κB p100, which acts as an inhibitor, and TNF receptor–associated receptor 3 (TRAF3); however, a role for TRAF3 in RANKL-mediated...

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Autori principali: Xiu, Yan, Xu, Hao, Zhao, Chen, Li, Jinbo, Morita, Yoshikazu, Yao, Zhenqiang, Xing, Lianping, Boyce, Brendan F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871219/
https://ncbi.nlm.nih.gov/pubmed/24316970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66947
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