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TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
Inflammaging induces osteoporosis by promoting bone destruction and inhibiting bone formation. TRAF3 limits bone destruction by inhibiting RANKL-induced NF-κB signaling in osteoclast precursors. However, the role of TRAF3 in mesenchymal progenitor cells (MPCs) is unknown. Mice with TRAF3 deleted in...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6595054/ https://ncbi.nlm.nih.gov/pubmed/31243287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10677-0 |
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