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NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism
TNF and RANKL mediate bone destruction in common bone diseases, including osteoarthritis and RA. They activate NF-κB canonical signaling directly in osteoclast precursors (OCPs) to induce osteoclast formation in vitro. However, unlike RANKL, TNF does not activate the alternative NF-κB pathway effici...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2752069/ https://ncbi.nlm.nih.gov/pubmed/19770515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38716 |
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