Total saponin from Anemone flaccida Fr. Schmidt abrogates osteoclast differentiation and bone resorption via the inhibition of RANKL-induced NF-κB, JNK and p38 MAPKs activation

Osteoclasts, bone-specialized multinucleated cells, are responsible for bone destructive diseases such as rheumatoid arthritis and osteoporosis. Natural plant-derived products have received substantial attention given their potential therapeutic and preventive activities against bone destructive dis...

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Vydáno v:J Transl Med
Hlavní autoři: Kong, Xiangying, Wu, Wenbin, Yang, Yue, Wan, Hongye, Li, Xiaomin, Zhong, Michun, Zhao, Hongyan, Su, Xiaohui, Jia, Shiwei, Ju, Dahong, Lin, Na
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372222/
https://ncbi.nlm.nih.gov/pubmed/25889035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0440-1
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