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Blockade of JNK and NFAT Pathways Attenuates Orthopedic Particle-Stimulated Osteoclastogenesis of Human Osteoclast Precursors and Murine Calvarial Osteolysis

Particles released from orthopedic implants attract immune host defense cells to the bone-implant interface and contribute to development of inflammation. The inflammatory microenvironment supports recruitment and differentiation of osteoclasts, the primary culprit of osteolysis. Therefore, understa...

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Detalhes bibliográficos
Main Authors: Yamanaka, Yasuhiro, Clohisy, John C.F., Ito, Hiroshi, Matsuno, Takeo, Abu-Amer, Yousef
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493691/
https://ncbi.nlm.nih.gov/pubmed/22847537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.22200
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