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Impediment of NEMO Oligomerization Inhibits Osteoclastogenesis and Osteolysis
The transcription factor NF-κB is essential for osteoclastogenesis and is considered an immune-modulator of rheumatoid arthritis and inflammatory osteolysis. Activation of NF-κB subunits is regulated by the upstream IκB kinase (IKK) complex which contains IKKα, IKKβ, and IKKγ; the latter also known...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3315188/ https://ncbi.nlm.nih.gov/pubmed/19830703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22364 |
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