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Impediment of NEMO Oligomerization Inhibits Osteoclastogenesis and Osteolysis

The transcription factor NF-κB is essential for osteoclastogenesis and is considered an immune-modulator of rheumatoid arthritis and inflammatory osteolysis. Activation of NF-κB subunits is regulated by the upstream IκB kinase (IKK) complex which contains IKKα, IKKβ, and IKKγ; the latter also known...

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Bibliografiska uppgifter
Huvudupphovsmän: Darwech, Isra, Otero, Jesse, Alhawagri, Muhammad, Dai, Simon, Abu-Amer, Yousef
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315188/
https://ncbi.nlm.nih.gov/pubmed/19830703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22364
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