Lobolide, a diterpene, blockades the NF-κB pathway and p38 and ERK MAPK activity in macrophages in vitro

AIM: Recent studies have shown that constitutive activation of the nuclear factor κB (NF-κB) plays a key role in chronic inflammation and cancers. The aim of this study was to characterize lobolide, a cembrane diterpene, as a drug candidate targeting the NF-κB signaling pathway. METHODS: A HEK 293/N...

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Sonraí Bibleagrafaíochta
Main Authors: Lv, Xiao-fen, Chen, Si-han, Li, Jie, Fang, Jian-ping, Guo, Yue-wei, Ding, Kan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2012
Ábhair:
Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002701/
https://ncbi.nlm.nih.gov/pubmed/22922340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.100
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