Lobolide, a diterpene, blockades the NF-κB pathway and p38 and ERK MAPK activity in macrophages in vitro

AIM: Recent studies have shown that constitutive activation of the nuclear factor κB (NF-κB) plays a key role in chronic inflammation and cancers. The aim of this study was to characterize lobolide, a cembrane diterpene, as a drug candidate targeting the NF-κB signaling pathway. METHODS: A HEK 293/N...

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Bibliografiske detaljer
Main Authors:	Lv, Xiao-fen, Chen, Si-han, Li, Jie, Fang, Jian-ping, Guo, Yue-wei, Ding, Kan
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2012
Fag:	Original Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4002701/ https://ncbi.nlm.nih.gov/pubmed/22922340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.100
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Lobolide, a diterpene, blockades the NF-κB pathway and p38 and ERK MAPK activity in macrophages in vitro

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