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PRMT5 inhibition attenuates cartilage degradation by reducing MAPK and NF-κB signaling

OBJECTIVES: A role for the type II arginine methyltransferase PRMT5 in various human diseases has been identified. In this study, the potential mechanism underlying the involvement of PRMT5 in the pathological process leading to osteoarthritis (OA) was investigated. METHODS: PRMT5 expression in cart...

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書目詳細資料
發表在:Arthritis Res Ther
Main Authors: Dong, Yonghui, Wang, Ping, Yang, Yongguang, Huang, Jincheng, Dai, Zhipeng, Zheng, Wendi, Li, Zhen, Yao, Zheng, Zhang, Hongjun, Zheng, Jia
格式: Artigo
語言:Inglês
出版: BioMed Central 2020
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650297/
https://ncbi.nlm.nih.gov/pubmed/32887644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-020-02304-x
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