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PRMT5 inhibition attenuates cartilage degradation by reducing MAPK and NF-κB signaling

OBJECTIVES: A role for the type II arginine methyltransferase PRMT5 in various human diseases has been identified. In this study, the potential mechanism underlying the involvement of PRMT5 in the pathological process leading to osteoarthritis (OA) was investigated. METHODS: PRMT5 expression in cart...

詳細記述

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書誌詳細
出版年:Arthritis Res Ther
主要な著者: Dong, Yonghui, Wang, Ping, Yang, Yongguang, Huang, Jincheng, Dai, Zhipeng, Zheng, Wendi, Li, Zhen, Yao, Zheng, Zhang, Hongjun, Zheng, Jia
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650297/
https://ncbi.nlm.nih.gov/pubmed/32887644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-020-02304-x
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