An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

The sequence of events that initiates T cell signaling is dictated by the specificities and order of activation of the tyrosine kinases that signal downstream of the T cell receptor. Using a platform that combines exhaustive point-mutagenesis of peptide substrates, bacterial surface-display, cell so...

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Bibliographische Detailangaben
Veröffentlicht in:eLife
Hauptverfasser: Shah, Neel H, Wang, Qi, Yan, Qingrong, Karandur, Deepti, Kadlecek, Theresa A, Fallahee, Ian R, Russ, William P, Ranganathan, Rama, Weiss, Arthur, Kuriyan, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2016
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5089863/
https://ncbi.nlm.nih.gov/pubmed/27700984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.20105
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