Merosin-deficient congenital muscular dystrophy. Partial genetic correction in two mouse models.

Humans and mice with deficiency of the alpha2 subunit of the basement membrane protein laminin-2/merosin suffer from merosin-deficient congenital muscular dystrophy (MCMD). We have expressed a human laminin alpha2 chain transgene under the regulation of a muscle-specific creatine kinase promoter in...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Kuang, W, Xu, H, Vachon, P H, Liu, L, Loechel, F, Wewer, U M, Engvall, E
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508948/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9710454/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI3705
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