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Off target V(D)J recombination drives lymphomagenesis and is escalated by loss of the Rag2 C-terminus
Genome wide analysis of thymic lymphomas from Tp53(−/−) mice with wild-type or C-terminally truncated Rag2 revealed numerous off target, RAG-mediated DNA rearrangements. A significantly higher fraction of these errors mutated known and suspected oncogenes/tumor suppressor genes than did sporadic rea...
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| Izdano u: | Cell Rep |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5089067/ https://ncbi.nlm.nih.gov/pubmed/26365182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.034 |
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