A carregar...
Off target V(D)J recombination drives lymphomagenesis and is escalated by loss of the Rag2 C-terminus
Genome wide analysis of thymic lymphomas from Tp53(−/−) mice with wild-type or C-terminally truncated Rag2 revealed numerous off target, RAG-mediated DNA rearrangements. A significantly higher fraction of these errors mutated known and suspected oncogenes/tumor suppressor genes than did sporadic rea...
Na minha lista:
| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5089067/ https://ncbi.nlm.nih.gov/pubmed/26365182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.034 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|