RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of ‘alternative NHEJ’

DNA double-stranded breaks (DSBs) can be repaired by several mechanisms, including classical NHEJ (c-NHEJ) and a poorly defined, error-prone process termed alternative NHEJ (a-NHEJ). How cells choose between these alternatives to join physiologic DSBs remains unknown. Here, we show that deletion of...

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Detalhes bibliográficos
Main Authors: Gigi, Vered, Lewis, Susanna, Shestova, Olga, Mijušković, Martina, Deriano, Ludovic, Meng, Wenzhao, Luning Prak, Eline T., Roth, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041462/
https://ncbi.nlm.nih.gov/pubmed/24753404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku295
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