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Novel roles for RAG2's acidic hinge: restricting pathway choice and promoting genomic stability
V(D)J recombination-associated DNA double-strand breaks (DSBs) are normally repaired by the high fidelity, classical non-homologous end joining (cNHEJ) machinery. Previous studies implicated the RAG/DNA post-cleavage complex (PCC) in regulating pathway choice by preventing access to inappropriate re...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4008148/ https://ncbi.nlm.nih.gov/pubmed/23994475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.07.041 |
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