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The RAG2 C-terminus suppresses genomic instability and lymphomagenesis
Misrepair of DNA double-strand breaks (DSBs) produced by the V(D)J recombinase (the RAG1/RAG2 proteins) at immunoglobulin (Ig) and T cell receptor (Tcr) loci has been implicated in pathogenesis of lymphoid malignancies in humans(1) and in mice(2–7). Defects in DNA damage response factors such as ATM...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3174233/ https://ncbi.nlm.nih.gov/pubmed/21368836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09755 |
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