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A New Take on V(D)J Recombination: Transcription Driven Nuclear and Chromatin Reorganization in Rag-Mediated Cleavage

It is nearly 30 years since the Alt lab first put forward the accessibility model, which proposes that cleavage of the various antigen receptor loci is controlled by lineage and stage specific factors that regulate RAG access. Numerous labs have since demonstrated that locus opening is regulated at...

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Detalhes bibliográficos
Main Authors: Chaumeil, Julie, Skok, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853590/
https://ncbi.nlm.nih.gov/pubmed/24367365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00423
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