Higher-order looping and nuclear organization of antigen receptor loci facilitate targeted RAG cleavage and regulated rearrangement in recombination centers

V(D)J recombination is essential for generating a diverse array of B and T cell receptors that can recognize and combat foreign antigen. As with any recombination event, tight control is essential to prevent the occurrence of genetic anomalies that drive cellular transformation. One important aspect...

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Bibliografiske detaljer
Main Authors: Chaumeil, Julie, Micsinai, Mariann, Ntziachristos, Panagiotis, Deriano, Ludovic, Wang, Joy M-H, Ji, Yanhong, Nora, Elphege P., Rodesch, Matthew J., Jeddeloh, Jeffrey A., Aifantis, Iannis, Kluger, Yuval, Schatz, David G., Skok, Jane A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664546/
https://ncbi.nlm.nih.gov/pubmed/23416051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.01.024
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