Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways

V(D)J recombination entails double-stranded DNA cleavage at the antigen receptor loci by the RAG1/2 proteins, which recognize conserved recombination signal sequences (RSSs) adjoining variable (V), diversity (D) and joining (J) gene segments. After cleavage, RAG1/2 remain associated with the coding...

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Bibliografiska uppgifter
Huvudupphovsmän: Arnal, Suzzette M., Holub, Abigail J., Salus, Sandra S., Roth, David B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2010
Ämnen:
Genome Integrity, Repair and Replication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875030/
https://ncbi.nlm.nih.gov/pubmed/20139091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1252
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