Generation of Genetically Engineered Precursor T-Cells From Human Umbilical Cord Blood Using an Optimized Alpharetroviral Vector Platform

Retroviral engineering of hematopoietic stem cell-derived precursor T-cells (preTs) opens the possibility of targeted T-cell transfer across human leukocyte antigen (HLA)-barriers. Alpharetroviral vectors exhibit a more neutral integration pattern thereby reducing the risk of insertional mutagenesis...

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Publicado en:Mol Ther
Autores principales: Hübner, Juwita, Hoseini, Shahabuddin S, Suerth, Julia D, Hoffmann, Dirk, Maluski, Marcel, Herbst, Jessica, Maul, Holger, Ghosh, Arnab, Eiz-Vesper, Britta, Yuan, Qinggong, Ott, Michael, Heuser, Michael, Schambach, Axel, Sauer, Martin G
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088766/
https://ncbi.nlm.nih.gov/pubmed/27138041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.89
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