Chimeric antigen receptor–induced BCL11B suppression propagates NK-like cell development

The transcription factor B cell CLL/lymphoma 11B (BCL11B) is indispensable for T lineage development of lymphoid progenitors. Here, we show that chimeric antigen receptor (CAR) expression during early phases of ex vivo generation of lymphoid progenitors suppressed BCL11B, leading to suppression of T...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Maluski, Marcel, Ghosh, Arnab, Herbst, Jessica, Scholl, Vanessa, Baumann, Rolf, Huehn, Jochen, Geffers, Robert, Meyer, Johann, Maul, Holger, Eiz-Vesper, Britta, Krueger, Andreas, Schambach, Axel, van den Brink, Marcel R.M., Sauer, Martin G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877334/
https://ncbi.nlm.nih.gov/pubmed/31479431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126350
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