Dynamics of Thrombin Generation and Flux from Clots during Whole Human Blood Flow over Collagen/Tissue Factor Surfaces

Coagulation kinetics are well established for purified blood proteases or human plasma clotting isotropically. However, less is known about thrombin generation kinetics and transport within blood clots formed under hemodynamic flow. Using microfluidic perfusion (wall shear rate, 200 s(−1)) of corn t...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Zhu, Shu, Lu, Yichen, Sinno, Talid, Diamond, Scott L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087723/
https://ncbi.nlm.nih.gov/pubmed/27605669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.754671
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