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Multiscale simulation of thrombus growth and vessel occlusion triggered by collagen/tissue factor using a data-driven model of combinatorial platelet signalling

During clotting under flow, platelets bind and activate on collagen and release autocrinic factors such as ADP and thromboxane, while tissue factor (TF) on the damaged wall leads to localized thrombin generation. Towards patient-specific simulation of thrombosis, a multiscale approach was developed...

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Detalhes bibliográficos
Publicado no:Math Med Biol
Main Authors: Lu, Yichen, Lee, Mei Yan, Zhu, Shu, Sinno, Talid, Diamond, Scott L
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798174/
https://ncbi.nlm.nih.gov/pubmed/27672182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/imammb/dqw015
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