LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity

Studies of the genetic factors associated with human autoimmune disease suggest a multigenic origin of susceptibility; however, how these factors interact and through which tolerance pathways they operate generally remain to be defined. One key checkpoint occurs through the activity of the autoimmun...

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Vydáno v:J Clin Invest
Hlavní autoři: Proekt, Irina, Miller, Corey N., Jeanne, Marion, Fasano, Kayla J., Moon, James J., Lowell, Clifford A., Gould, Douglas B., Anderson, Mark S., DeFranco, Anthony L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087700/
https://ncbi.nlm.nih.gov/pubmed/27571405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84440
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