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LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity
Studies of the genetic factors associated with human autoimmune disease suggest a multigenic origin of susceptibility; however, how these factors interact and through which tolerance pathways they operate generally remain to be defined. One key checkpoint occurs through the activity of the autoimmun...
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| 出版年: | J Clin Invest |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5087700/ https://ncbi.nlm.nih.gov/pubmed/27571405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84440 |
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