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Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation

Deletion of lyn, a Src-family tyrosine kinase expressed by B, myeloid, and dendritic cells (DCs), triggers lupus-like disease in mice, characterized by autoantibody production and renal immune complex deposition leading to chronic glomerulonephritis. B cells from these mice are hyperactive to antige...

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Detaylı Bibliyografya
Asıl Yazarlar: Lamagna, Chrystelle, Scapini, Patrizia, van Ziffle, Jessica A., DeFranco, Anthony L., Lowell, Clifford A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761623/
https://ncbi.nlm.nih.gov/pubmed/23940344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300617110
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