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B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice

Lyn kinase deficient mice represent a well established genetic model of autoimmune/autoinflammatory disease that resembles systemic lupus erythematosus. We report that IL-10 plays a crucial immunosuppressive role in this model, modulating the inflammatory component of the disease caused by myeloid a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Scapini, Patrizia, Lamagna, Chrystelle, Hu, Yongmei, Lee, Karim, Tang, Qizhi, DeFranco, Anthony L., Lowell, Clifford A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193193/
https://ncbi.nlm.nih.gov/pubmed/21911371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107913108
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