Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling

It is widely accepted that the essential role of TRAF6 in vivo is to generate the Lys63-linked ubiquitin (K63-Ub) chains needed to activate the “master” protein kinase TAK1. Here, we report that TRAF6 E3 ligase activity contributes to but is not essential for the IL-1–dependent formation of K63-Ub c...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Strickson, Sam, Emmerich, Christoph H., Goh, Eddy T. H., Zhang, Jiazhen, Kelsall, Ian R., Macartney, Thomas, Hastie, C. James, Knebel, Axel, Peggie, Mark, Marchesi, Francesco, Arthur, J. Simon C., Cohen, Philip
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410814/
https://ncbi.nlm.nih.gov/pubmed/28404732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702367114
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