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The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

The compound BAY 11-7082 inhibits IκBα [inhibitor of NF-κB (nuclear factor κB)α] phosphorylation in cells and has been used to implicate the canonical IKKs (IκB kinases) and NF-κB in >350 publications. In the present study we report that BAY 11-7082 does not inhibit the IKKs, but suppresses their...

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Hlavní autoři: Strickson, Sam, Campbell, David G., Emmerich, Christoph H., Knebel, Axel, Plater, Lorna, Ritorto, Maria Stella, Shpiro, Natalia, Cohen, Philip
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3685219/
https://ncbi.nlm.nih.gov/pubmed/23441730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20121651
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