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Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells
The Src-family tyrosine kinase Lyn negatively regulates BCR signaling and also myeloid cell activity. Mice deficient in Lyn have substantially decreased numbers of peripheral B cells, despite spontaneously producing IgG anti-DNA antibodies. We have examined the mechanism underlying the B cell deplet...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3517141/ https://ncbi.nlm.nih.gov/pubmed/21928281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201141708 |
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