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Lyn deficiency affects B cell maturation as well as survival

Lyn, a Src-family protein tyrosine kinase expressed in B lymphocytes, contributes to initiation of BCR signaling and is also responsible for feedback inhibition of BCR signaling. Lyn-deficient mice have a decreased number of follicular B cells and also spontaneously develop a lupus-like autoimmunity...

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Detalhes bibliográficos
Main Authors: Shahaf, Gitit, Gross, Andrew J., Sternberg-Simon, Michal, Kaplan, Deborah, DeFranco, Anthony L., Mehr, Ramit
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516919/
https://ncbi.nlm.nih.gov/pubmed/22057631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201141940
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