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Lyn deficiency affects B cell maturation as well as survival
Lyn, a Src-family protein tyrosine kinase expressed in B lymphocytes, contributes to initiation of BCR signaling and is also responsible for feedback inhibition of BCR signaling. Lyn-deficient mice have a decreased number of follicular B cells and also spontaneously develop a lupus-like autoimmunity...
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| Main Authors: | , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3516919/ https://ncbi.nlm.nih.gov/pubmed/22057631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201141940 |
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