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Developmental Acquisition of the Lyn–CD22–SHP-1 Inhibitory Pathway Promotes B Cell Tolerance
To better understand whether autoimmunity in Lyn-deficient mice arises from compromised central or peripheral B cell tolerance, we examined BCR signaling properties of wild type and Lyn-deficient B cells at different stages of development. Wild-type mature follicular B cells were less sensitive to B...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840041/ https://ncbi.nlm.nih.gov/pubmed/19380785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803941 |
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