In vitro metabolism of piperaquine is primarily mediated by CYP3A4

1. Piperaquine (PQ) is part of a first-line treatment regimen for Plasmodium falciparum malaria recommended by the World Health Organization (WHO). We aimed to determine the major metabolic pathway(s) of PQ in vitro. A reliable, validated tandem mass spectrometry method was developed. Concentrations...

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Publicado en:Xenobiotica
Main Authors: Lee, Tina Ming-Na, Huang, Liusheng, Johnson, Marla K., Lizak, Patricia, Kroetz, Deanna, Aweeka, Francesca, Parikh, Sunil
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087332/
https://ncbi.nlm.nih.gov/pubmed/22671777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/00498254.2012.693972
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