Determination of the antimalarial drug piperaquine in small volume pediatric plasma samples by LC–MS/MS

AIM: Determination of piperaquine (PQ) in pediatric plasma requires a method with a small sample volume. RESULTS: We report a sensitive LC–MS/MS method for quantitation of PQ with only 25 µI human plasma. Using a deuterated internal standard (PQ-d(6)), an analytical PFP column, APCI(+) as the ion so...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Bioanalysis
Prif Awduron: Kjellin, Linda L, Dorsey, Grant, Rosenthal, Philip J, Aweeka, Francesca, Huang, Liusheng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321809/
https://ncbi.nlm.nih.gov/pubmed/25529877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/bio.14.254
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