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Determination of lumefantrine in small-volume human plasma by LC–MS/MS: using a deuterated lumefantrine to overcome matrix effect and ionization saturation

BACKGROUND: To support pediatric study, a method to determine lumefantrine (LF) with small sample volume is needed. Matrix effect (ME) is a daunting issue in LF quantification in human plasma with LC MS/MS. RESULTS: Here we report an LC–MS/MS method with a deuterated LF as the internal standard (IS)...

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Detalhes bibliográficos
Main Authors: Huang, Liusheng, Li, Xiaohua, Marzan, Florence, Lizak, Patricia S, Aweeka, Francesca T
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321395/
https://ncbi.nlm.nih.gov/pubmed/22250798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/bio.11.303
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