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Determination of lumefantrine in small-volume human plasma by LC–MS/MS: using a deuterated lumefantrine to overcome matrix effect and ionization saturation
BACKGROUND: To support pediatric study, a method to determine lumefantrine (LF) with small sample volume is needed. Matrix effect (ME) is a daunting issue in LF quantification in human plasma with LC MS/MS. RESULTS: Here we report an LC–MS/MS method with a deuterated LF as the internal standard (IS)...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3321395/ https://ncbi.nlm.nih.gov/pubmed/22250798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/bio.11.303 |
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