Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma

Uveal melanoma (UM) is the most common cancer of the eye in adults. Many UM patients develop metastases for which no curative treatment has been identified. Novel therapeutic approaches are therefore urgently needed. UM is characterized by mutations in the genes GNAQ and GNA11 which activate the PKC...

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Udgivet i:Oncotarget
Main Authors: Carita, Guillaume, Frisch-Dit-Leitz, Estelle, Dahmani, Ahmed, Raymondie, Chloé, Cassoux, Nathalie, Piperno-Neumann, Sophie, Némati, Fariba, Laurent, Cécile, De Koning, Leanne, Halilovic, Ensar, Jeay, Sebastien, Wylie, Andrew, Emery, Caroline, Roman-Roman, Sergio, Schoumacher, Marie, Decaudin, Didier
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Priority Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085101/
https://ncbi.nlm.nih.gov/pubmed/27507190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9552
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