Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma

Uveal melanoma (UM) is the most common cancer of the eye in adults. Many UM patients develop metastases for which no curative treatment has been identified. Novel therapeutic approaches are therefore urgently needed. UM is characterized by mutations in the genes GNAQ and GNA11 which activate the PKC...

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Publicado no:Oncotarget
Main Authors: Carita, Guillaume, Frisch-Dit-Leitz, Estelle, Dahmani, Ahmed, Raymondie, Chloé, Cassoux, Nathalie, Piperno-Neumann, Sophie, Némati, Fariba, Laurent, Cécile, De Koning, Leanne, Halilovic, Ensar, Jeay, Sebastien, Wylie, Andrew, Emery, Caroline, Roman-Roman, Sergio, Schoumacher, Marie, Decaudin, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085101/
https://ncbi.nlm.nih.gov/pubmed/27507190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9552
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