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Selumetinib-based therapy in uveal melanoma patient-derived xenografts
The prognosis of metastatic uveal melanoma (UM) is among the worst of all human cancers. The identification of near-ubiquitous GNAQ/GNA11 mutations and the activation of MAPK signaling in UM have raised hopes of more effective, targeted therapies, based on MEK inhibition, for example. We evaluated t...
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| Опубликовано в: : | Oncotarget |
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| Главные авторы: | , , , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Impact Journals LLC
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5955168/ https://ncbi.nlm.nih.gov/pubmed/29774094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24670 |
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