Selumetinib-based therapy in uveal melanoma patient-derived xenografts

The prognosis of metastatic uveal melanoma (UM) is among the worst of all human cancers. The identification of near-ubiquitous GNAQ/GNA11 mutations and the activation of MAPK signaling in UM have raised hopes of more effective, targeted therapies, based on MEK inhibition, for example. We evaluated t...

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Pubblicato in:Oncotarget
Autori principali: Decaudin, Didier, El Botty, Rania, Diallo, Béré, Massonnet, Gerald, Fleury, Justine, Naguez, Adnan, Raymondie, Chloé, Davies, Emma, Smith, Aaron, Wilson, Joanne, Howes, Colin, Smith, Paul D., Cassoux, Nathalie, Piperno-Neumann, Sophie, Roman-Roman, Sergio, Némati, Fariba
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955168/
https://ncbi.nlm.nih.gov/pubmed/29774094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24670
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