Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

The synthesis of cholesterol and its uptake from plasma LDL are regulated by two membrane-bound transcription factors, designated sterol regulatory element binding protein-1 and -2 (SREBP-1 and SREBP-2). Here, we used the technique of homologous recombination to generate mice with disruptions in the...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Shimano, H, Shimomura, I, Hammer, R E, Herz, J, Goldstein, J L, Brown, M S, Horton, J D
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508404/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9329978/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119746
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