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Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs
Parthenolide is a naturally occurring terpene with promising anticancer properties, in particular in the context of acute myeloid leukemia (AML). Optimization of this natural product has been challenged by limited opportunities for the late-stage functionalization of this molecule without affecting...
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| Veröffentlicht in: | Bioorg Med Chem |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5083853/ https://ncbi.nlm.nih.gov/pubmed/27396927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.06.028 |
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